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Nizoral Tablets Lawsuits

Have you taken Nizoral (ketoconazole) tablets and developed liver injuries, adrenal gland difficulties or other problems or side effects? If so, you may need to contact a personal injury attorney who may be able to help you receive compensation for your Nizoral injury.

Nizoral tablets contain the active ingredient ketoconazole. Ketoconazole is a kind of medication that is referred to as an antifungal. It is used in the treatment of infection from yeasts and fungi.

Nizoral tablets kill fungi and yeasts by interfering with their cell membranes. Nizoral tablets stops the fungi from making a substance that is known as ergosterol. Ergosterol is an essential part of fungal cell membranes. By interfering with ergosterol production, the fungal cell membrane is disrupted. This results in holes forming in the fungal cell membrane.

In order for fungi to live, the cell membranes are essential. The cell membranes prevent the content of the cells from leaking out, and they keep unwanted substances from getting into the cells. When Nizoral tablets cause holes to form in the fungal cell membranes, vital components of the fungal cells leak out. This kills the fungi and treats the infection.

Nizoral tablets are used in the treatment of hair, skin or mucous membranes. Mucous membranes include the moist linings of the nose, mouth or vagina. These are areas that cannot be treated with topical Nizoral as a result of the site or extent of the infection or that cannot be treated with other antifungals.

However, according to the U.S. Food and Drug Administration (FDA), Nizoral tablets can lead to potentially fatal liver injury and adrenal gland insufficiency. On July 26, 2013, the FDA released a safety alert and required changes to Johnson & Johnson’s Janssen Pharmaceuticals Nizoral tablets labels. The European Medicines Agency (EMA) recommended suspension of marketing ketoconazole after the Committee on Medicinal Products for Human Use determined that the risks do not outweigh the benefits.

The FDA required a label change to Nizoral tablets and recommends limited use of the medication. The Nizoral label now says, "Nizoral Tablets should be used only when other effective antifungal therapy is not available or tolerated and the potential benefits are considered to outweigh the potential risks."

The FDA and EMA warnings apply only to Nizoral oral tablets. Nizoral tablets usually are prescribed in 200-mg tablets. This medication was prescribed more than 600,000 times in the United States in 2012.

Side Effects of Nizoral

In addition to liver injuries and adrenal gland problems, Nizoral tablets may cause some other serious side effects. These include:

  • Dangerous drug interactions that include life-threatening problems like heart dysrhythmia
  • Tingly feeling or numbness
  • Thoughts of hurting yourself, confusion or severe depression
  • Fainting, dizziness, pounding or fast heartbeat
  • Unusual weakness, easy bruising or bleeding
  • Dark urine, clay-colored stools, stomach pain, loss of appetite, nausea, low fever, jaundice (yellowing of your skin and/or the whites of your eyes)

If you or a loved one has developed adrenal gland insufficiency, liver problems or any other serious side effects and complications after taking Nizoral tablets for fungal or yeast infections, you may want to talk to a personal injury attorney and let him or her evaluate your case.